| First Author | Lempereur A | Year | 2018 |
| Journal | Dev Biol | Volume | 434 |
| Issue | 2 | Pages | 292-303 |
| PubMed ID | 29253505 | Mgi Jnum | J:257914 |
| Mgi Id | MGI:6116606 | Doi | 10.1016/j.ydbio.2017.12.006 |
| Citation | Lempereur A, et al. (2018) The TGFbeta pathway is a key player for the endothelial-to-hematopoietic transition in the embryonic aorta. Dev Biol 434(2):292-303 |
| abstractText | The embryonic aorta produces hematopoietic stem and progenitor cells from a hemogenic endothelium localized in the aortic floor through an endothelial to hematopoietic transition. It has been long proposed that the Bone Morphogenetic Protein (BMP)/Transforming Growth Factor ss (TGFss) signaling pathway was implicated in aortic hematopoiesis but the very nature of the signal was unknown. Here, using thorough expression analysis of the BMP/TGFss signaling pathway members in the endothelial and hematopoietic compartments of the aorta at pre-hematopoietic and hematopoietic stages, we show that the TGFss pathway is preferentially balanced with a prominent role of Alk1/TgfssR2/Smad1 and 5 on both chicken and mouse species. Functional analysis using embryonic stem cells mutated for Acvrl1 revealed an enhanced propensity to produce hematopoietic cells. Collectively, we reveal that TGFss through the Alk1/TgfssR2 receptor axis is acting on endothelial cells to produce hematopoiesis. |
