| First Author | Triscott J | Year | 2018 |
| Journal | Cancer Discov | Volume | 8 |
| Issue | 6 | Pages | 682-685 |
| PubMed ID | 29858226 | Mgi Jnum | J:262549 |
| Mgi Id | MGI:6162409 | Doi | 10.1158/2159-8290.CD-18-0369 |
| Citation | Triscott J, et al. (2018) Prostate Power Play: Does Pik3ca Accelerate Pten-Deficient Cancer Progression?. Cancer Discov 8(6):682-685 |
| abstractText | PI3K pathway alterations are frequently recurrent in metastatic prostate cancer and are associated with the development of currently incurable castration-resistant disease. Candidate inhibitors that target single PI3K pathway members lack efficacy as demonstrated in multiple clinical trials. In this issue, Pearson and colleagues examine the functional importance of co-occurring PIK3CA and PTEN aberrations using a novel mouse model and demonstrate a synergistic acceleration of tumorigenesis that may be responsible for de novo metastatic prostate cancer. Cancer Discov; 8(6); 682-5. (c)2018 AACRSee related article by Pearson et al., p. 764. |
