| First Author | Kim HR | Year | 2017 |
| Journal | Lab Anim Res | Volume | 33 |
| Issue | 2 | Pages | 132-139 |
| PubMed ID | 28747979 | Mgi Jnum | J:262119 |
| Mgi Id | MGI:6156944 | Doi | 10.5625/lar.2017.33.2.132 |
| Citation | Kim HR, et al. (2017) Comparison of humoral and cell-mediated immunity in three different C57BL/6N mouse substrains. Lab Anim Res 33(2):132-139 |
| abstractText | Adaptive immunity is a type of immune response mediated by T and B cells, and is important response for immune response amplification and memory. In this study, the adaptive immunologic properties of C57BL/6NKorl substrain were compared with those of two other C57BL/6N substrains. There were no significant differences between the C57BL/6NKorl and the two other C57BL/6N substrains in the histological structures of the thymus and spleen, which are immunologic organs containing T cell and B cells. In addition, flow cytometric analysis did not reveal any significant differences in the distribution of T and B cell populations of the three substrains. To evaluate cell-mediated immunity of T cells in the three different substrains, we treated isolated T cells from spleen with Con A. The T cells of C57BL/6NKorl showed Con A-dependent proliferation of T cells at lower cell number than those in T cells from the other two C57BL/6N substrains. B cell-mediated humoral immune responses were not significant different among the three substrains. Thus, the results of this study provide evidence that C57BL/6NKorl mice are similar to those two other C57BL/6N substrains in humoral immunity, but C57BL/6NKorl has stronger response in cell mediated immunity. |
