| First Author | Wang X | Year | 2018 |
| Journal | Nat Commun | Volume | 9 |
| Issue | 1 | Pages | 4854 |
| PubMed ID | 30451860 | Mgi Jnum | J:268353 |
| Mgi Id | MGI:6267586 | Doi | 10.1038/s41467-018-07405-5 |
| Citation | Wang X, et al. (2018) Memory formation and long-term maintenance of IL-7Ralpha(+) ILC1s via a lymph node-liver axis. Nat Commun 9(1):4854 |
| abstractText | Natural killer (NK) cells are reported to have immunological memory, with CD49a(+) liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Ralpha, are generated in the lymph nodes (LNs) and require IL-7R signaling to maintain their longevity in the liver. Hapten sensitization initiates CXCR3-dependent recruitment of IL-7Ralpha(+) ILC1s into skin-draining LNs, where they are primed and acquire hapten-specific memory potential. Memory IL-7Ralpha(+) ILC1s then exit draining LNs and are preferentially recruited, via CXCR6, to reside in the liver. Moreover, long-term blockade of IL-7R signaling significantly reduces ILC1-mediated memory responses. Thus, our results identify a memory IL-7Ralpha(+) ILC1 population and reveal a LN-liver axis that is essential for ILC1 memory generation and long-term maintenance. |
