| First Author | Hashimoto-Hill S | Year | 2018 |
| Journal | Nat Commun | Volume | 9 |
| Issue | 1 | Pages | 3896 |
| PubMed ID | 30254197 | Mgi Jnum | J:268515 |
| Mgi Id | MGI:6268094 | Doi | 10.1038/s41467-018-06341-8 |
| Citation | Hashimoto-Hill S, et al. (2018) RARalpha supports the development of Langerhans cells and langerin-expressing conventional dendritic cells. Nat Commun 9(1):3896 |
| abstractText | Langerhans cells (LC) are the prototype langerin-expressing dendritic cells (DC) that reside specifically in the epidermis, but langerin-expressing conventional DCs also reside in the dermis and other tissues, yet the factors that regulate their development are unclear. Because retinoic acid receptor alpha (RARalpha) is highly expressed by LCs, we investigate the functions of RARalpha and retinoic acid (RA) in regulating the langerin-expressing DCs. Here we show that the development of LCs from embryonic and bone marrow-derived progenitors and langerin(+ )conventional DCs is profoundly regulated by the RARalpha-RA axis. During LC differentiation, RARalpha is required for the expression of a LC-promoting transcription factor Runx3, but suppresses that of LC-inhibiting C/EBPbeta. RARalpha promotes the development of LCs and langerin(+) conventional DCs only in hypo-RA conditions, a function effectively suppressed at systemic RA levels. Our findings identify positive and negative regulatory mechanisms to tightly regulate the development of the specialized DC populations. |
