| First Author | Wang L | Year | 2018 |
| Journal | Sci Rep | Volume | 8 |
| Issue | 1 | Pages | 11396 |
| PubMed ID | 30061639 | Mgi Jnum | J:269796 |
| Mgi Id | MGI:6271558 | Doi | 10.1038/s41598-018-29827-3 |
| Citation | Wang L, et al. (2018) Repeated abortion in adulthood induces cognition impairment in aged mice. Sci Rep 8(1):11396 |
| abstractText | Age-related cognitive decline is one of the major aspects that impede successful aging in humans. Repeated abortion in adulthood can accelerate or aggravate cognitive deficiency during aging. Here we used repeated abortion in female mice adulthood and investigated the consequences of this treatment on cognitive performance during aging. We observed a substantial impairment of learning memory in 15 months old. This cognitive dysfunction was supported by Abeta elevation in CA region. Repeated abortion mice have uniform estrous cycles and decreased ERalpha expression in hypothalamus and hippocampus. Furthermore, repeated abortion not only significantly increased the HMGB1 expression in hippocampus but also increased the plasma and hippocampal protein levels of IL-1beta, IL-6, and TNF-alpha. Finally, we identified that MPP-induced cell apoptosis and increased HMGB1 expression as well as IL-1beta, IL-6, and TNF-alpha expression as following Abeta elevation. Taken together, our results identify possible molecular mechanisms underlying cognitive impairment during aging, and demonstrated the repeated abortion in adulthood on cognitive function in aged mice. |
