| First Author | Zhou X | Year | 2017 |
| Journal | Stem Cell Reports | Volume | 9 |
| Issue | 3 | Pages | 732-741 |
| PubMed ID | 28844657 | Mgi Jnum | J:271482 |
| Mgi Id | MGI:6275745 | Doi | 10.1016/j.stemcr.2017.07.019 |
| Citation | Zhou X, et al. (2017) Cytoplasmic and Nuclear TAZ Exert Distinct Functions in Regulating Primed Pluripotency. Stem Cell Reports 9(3):732-741 |
| abstractText | Mouse epiblast stem cells (mEpiSCs) and human embryonic stem cells (hESCs) are primed pluripotent stem cells whose self-renewal can be maintained through cytoplasmic stabilization and retention of beta-catenin. The underlying mechanism, however, remains largely unknown. Here, we show that cytoplasmic beta-catenin interacts with and retains TAZ, a Hippo pathway effector, in the cytoplasm. Cytoplasmic retention of TAZ promotes mEpiSC self-renewal in the absence of nuclear beta-catenin, whereas nuclear translocation of TAZ induces mEpiSC differentiation. TAZ is dispensable for naive mouse embryonic stem cell (mESC) self-renewal but required for the proper conversion of mESCs to mEpiSCs. The self-renewal of hESCs, like that of mEpiSCs, can also be maintained through the cytoplasmic retention of beta-catenin and TAZ. Our study indicates that how TAZ regulates cell fate depends on not only the cell type but also its subcellular localization. |
