| First Author | Hashimoto H | Year | 2018 |
| Journal | J Vet Med Sci | Volume | 80 |
| Issue | 4 | Pages | 662-666 |
| PubMed ID | 29445073 | Mgi Jnum | J:271729 |
| Mgi Id | MGI:6282118 | Doi | 10.1292/jvms.17-0641 |
| Citation | Hashimoto H, et al. (2018) Adiponectin deficiency-induced diabetes increases TNFalpha and FFA via downregulation of PPARalpha. J Vet Med Sci 80(4):662-666 |
| abstractText | Expression of peroxisome proliferator-activated receptor (PPAR) alpha was investigated in adiponectin knockout mice to elucidate the relationship between PPARalpha and adiponectin deficiency-induced diabetes. Adiponectin knockout (Adp(-/-)) mice were generated by gene targeting. Glucose tolerance test (GTT), insulin tolerance test (ITT), and organ sampling were performed in Adp(-/-) mice at the age of 10 weeks. PPARalpha, insulin, triglyceride, free fatty acid (FFA), and tumor necrosis factor alpha (TNFalpha) were analyzed from the sampled organs. Adp(-/-) mice showed impaired glucose tolerance and insulin resistance. Additionally, PPARalpha levels were decreased and plasma concentration of triglyceride, FFA and TNFalpha were increased. These data may indicate that insulin resistance in Adp(-/-) mice is likely caused by an increase in concentrations of TNFalpha and FFA via downregulation of PPARalpha. |
