| First Author | Piao Z | Year | 2017 |
| Journal | Cell Immunol | Volume | 318 |
| Pages | 23-28 | PubMed ID | 28601359 |
| Mgi Jnum | J:271931 | Mgi Id | MGI:6282318 |
| Doi | 10.1016/j.cellimm.2017.05.004 | Citation | Piao Z, et al. (2017) Osteopontin exacerbates Pseudomonas aeruginosa-induced bacteremia in mice. Cell Immunol 318:23-28 |
| abstractText | Osteopontin (OPN) is a multifunctional protein involved in various pathophysiological processes. However, the role of OPN in Pseudomonas aeruginosa-related sepsis is not yet clear. Here, we found that OPN expression was elevated in plasma and spleen samples from P. aeruginosa-infected mice. To determine the function of OPN in sepsis, we used wild-type (WT) and OPN-knockout (KO) mice with P. aeruginosa-induced bacteremia. We found that OPN-KO mice exhibited reduced mortality compared with WT mice and that OPN exacerbated spleen bleeding and functional impairment. OPN-KO mice exhibited reduced secretion of pro-inflammatory cytokines, such as interferon-gamma, interleukin (IL)-1beta, IL-12, and tumor necrosis factor-alpha, whereas levels of anti-inflammatory cytokine IL-10 and the leukocyte trafficking mediator macrophage inflammatory protein (MIP)-2 were not altered. Additionally, the percentages and absolute numbers of B cells were elevated in the spleens of OPN-KO mice. Thus, OPN promoted sepsis in P. aeruginosa-infected mice and potentially blocked B cell-dependent immunity. |
