| First Author | Fujimoto Y | Year | 2018 |
| Journal | Biol Pharm Bull | Volume | 41 |
| Issue | 2 | Pages | 182-189 |
| PubMed ID | 29386478 | Mgi Jnum | J:272237 |
| Mgi Id | MGI:6282986 | Doi | 10.1248/bpb.b17-00594 |
| Citation | Fujimoto Y, et al. (2018) The Role of Interleukin-19 in Contact Hypersensitivity. Biol Pharm Bull 41(2):182-189 |
| abstractText | Interleukin (IL)-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. The gastrointestinal tissues of IL-19 knockout mice show exacerbated experimental colitis mediated by the innate immune system and T cells. There is an increasing focus on the interaction and relationship of IL-19 with the function of T cells. Contact hypersensitivity (CHS) is T cell-mediated cutaneous inflammation. Therefore, we asked whether IL-19 causes CHS. We investigated the immunological role of IL-19 in CHS induced by 1-fluoro-2,4-dinitrofluorobenzene as a hapten. IL-19 was highly expressed in skin exposed to the hapten, and ear swelling was increased in IL-19 knockout mice. The exacerbation of the CHS response in IL-19 knockout mice correlated with increased levels of IL-17 and IL-6, but no alterations were noted in the production of interferon (IFN)gamma and IL-4 in the T cells of the lymph nodes. In addition to the effect on T cell response, IL-19 knockout mice increased production of inflammatory cytokines. These results show that IL-19 suppressed hapten-dependent skin inflammation in the elicitation phase of CHS. |
