| First Author | Chen Y | Year | 2019 |
| Journal | Am J Physiol Endocrinol Metab | Volume | 316 |
| Issue | 2 | Pages | E145-E155 |
| PubMed ID | 30398903 | Mgi Jnum | J:274423 |
| Mgi Id | MGI:6283291 | Doi | 10.1152/ajpendo.00196.2018 |
| Citation | Chen Y, et al. (2019) Repression of adipose vascular endothelial growth factor reduces obesity through adipose browning. Am J Physiol Endocrinol Metab 316(2):E145-E155 |
| abstractText | Obesity is the result of excessive energy accumulation and is associated with many diseases. We previously reported that universal repression of vascular endothelial growth factor (VEGF) leads to brown-like adipocyte development in white adipose tissues, and that these mice are resistant to obesity (Lu X et al. Endocrinology 153: 3123-3132, 2012). Using an adipose-specific VEGF repression mouse model (aP2-rtTR-krab(tg/+)/VEGF(tetO/tetO)), we show that adipose-specific VEGF repression can repeat the previous phenotypes, including adipose browning, increased energy consumption, and reduction in body weight. Expression of brown adipose-associated genes is increased, and white adipose-associated genes are downregulated under VEGF repression. Our study demonstrates that adipose-specific VEGF repression can lead to antiobesity activity through adipose browning and has potential clinical value. |
