| First Author | Tsubura A | Year | 1993 |
| Journal | Int J Oncol | Volume | 2 |
| Issue | 6 | Pages | 927-30 |
| PubMed ID | 21573648 | Mgi Jnum | J:13277 |
| Mgi Id | MGI:61483 | Doi | 10.3892/ijo.2.6.927 |
| Citation | Tsubura A, et al. (1993) Strain differences in neoplastic response to dmba-induced uterine vascular tumors in mice. Int J Oncol 2(6):927-30 |
| abstractText | We examined strain differences in neoplastic response to DMBA-induced uterine vascular tumors in mice. Female BALB/c, C57BL, C3H, SWR/J, GRS/A and DDD/1-Mtv-2 mice were treated with a single intraperitoneal injection (ip) of 1 mg of 7,12-dimethylbenz(a)anthracene (DMBA) at 4 weeks of age, and observed until they were 32 weeks of age. The BALB/c, C57BL, C3H strains showed a high incidence of uterine vascular tumors (87%, 93%, and 90%, respectively), while in contrast, the SWR/J, GRS/A, and DDD/1-Mtv-2 strains showed a low incidence (17%, 11% and 15%, respectively); these differences were striking. The mice of American origin (BALB/c, C57BL and C3H) appeared to be susceptible to DMBA, while those of European origin (SWR/J, GRS/A and DDD/1-Mtv-2) were resistant to the induction of uterine vascular tumors. |
