| First Author | Zhang M | Year | 2018 |
| Journal | Nat Immunol | Volume | 19 |
| Issue | 3 | Pages | 279-290 |
| PubMed ID | 29434353 | Mgi Jnum | J:282900 |
| Mgi Id | MGI:6358995 | Doi | 10.1038/s41590-018-0046-x |
| Citation | Zhang M, et al. (2018) Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. Nat Immunol 19(3):279-290 |
| abstractText | Deletion of master regulators of the B cell lineage reprograms B cells into T cells. Here we found that the transcription factor Hoxb5, which is expressed in uncommitted hematopoietic progenitor cells but is not present in cells committed to the B cell or T cell lineage, was able to reprogram pro-pre-B cells into functional early T cell lineage progenitors. This reprogramming started in the bone marrow and was completed in the thymus and gave rise to T lymphocytes with transcriptomes, hierarchical differentiation, tissue distribution and immunological functions that closely resembled those of their natural counterparts. Hoxb5 repressed B cell 'master genes', activated regulators of T cells and regulated crucial chromatin modifiers in pro-pre-B cells and ultimately drove the B cell fate-to-T cell fate conversion. Our results provide a de novo paradigm for the generation of functional T cells through reprogramming in vivo. |
