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Publication : The mouse as a model for the effects of MHC genes on human disease.

First Author  Allcock RJ Year  2000
Journal  Immunol Today Volume  21
Issue  7 Pages  328-32
PubMed ID  10871872 Mgi Jnum  J:63110
Mgi Id  MGI:1860467 Doi  10.1016/s0167-5699(00)01654-6
Citation  Allcock RJ, et al. (2000) The mouse as a model for the effects of MHC genes on human disease. Immunol Today 21(7):328-32
abstractText  As mice are often used to model human major histocompatibility complex (MHC)-associated diseases, it is important to understand how their MHC regions differ at the DNA level. The sequencing of the mouse MHC (H2 region) has enabled a detailed map of this region to be assembled for comparison with the human MHC. Here, Richard Allcock and colleagues outline the similarities between the human and mouse MHC regions and discuss notable differences that might affect disease models.
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