| First Author | Chang TH | Year | 2015 |
| Journal | J Immunol | Volume | 195 |
| Issue | 11 | Pages | 5367-79 |
| PubMed ID | 26503954 | Mgi Jnum | J:287707 |
| Mgi Id | MGI:6423246 | Doi | 10.4049/jimmunol.1402064 |
| Citation | Chang TH, et al. (2015) Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-kappaB Pathways along with TNFR-Associated Factor 6. J Immunol 195(11):5367-79 |
| abstractText | Tripartite motif (TRIM) protein TRIM5 of the primate species restricts replication of HIV and other retroviruses. Whereas primates have a single TRIM5 gene, the corresponding locus in the mouse has expanded during evolution, now containing more than eight related genes. Owing to the complexity of the genomic organization, a mouse homolog of TRIM5 has not been fully studied thus far. In the present study, we report that Trim12c (formerly Trim12-2) encodes a TRIM5-like protein with a ubiquitin ligase activity. Similar to the primate TRIM5, TRIM12c is expressed in the cytoplasm as a punctate structure and induced upon IFN and pathogen stimulation in macrophages and dendritic cells. We show that TRIM12c interacts with TRAF6, a key protein in the pathogen recognition receptor signaling, and reciprocally enhances their ubiquitination, leading to cooperative activation of IFN and NF-kappaB pathways. This study identifies TRIM12c as a mouse TRIM5 equivalent, critical for host innate immunity. |
