| First Author | Roberts A | Year | 2008 |
| Journal | Virus Res | Volume | 133 |
| Issue | 1 | Pages | 20-32 |
| PubMed ID | 17499378 | Mgi Jnum | J:286331 |
| Mgi Id | MGI:6403361 | Doi | 10.1016/j.virusres.2007.03.025 |
| Citation | Roberts A, et al. (2008) Animal models and vaccines for SARS-CoV infection. Virus Res 133(1):20-32 |
| abstractText | We summarize findings of SARS-CoV infections in several animal models each of which support viral replication in lungs accompanied by histopathological changes and/or clinical signs of illness to varying degrees. New findings are reported on SARS-CoV replication and associated pathology in two additional strains (C57BL/6 and 129S6) of aged mice. We also provide new comparative data on viral replication and associated pathology following infection of golden Syrian hamsters with various SARS-CoV strains and report the levels of neutralizing antibody titers following these infections and the cross-protective efficacy of infection with these strains in protecting against heterologous challenge. Finally, we summarize findings of a variety of vaccine approaches and discuss the available in vitro and in vivo data addressing the potential for disease enhancement following re-infection in animals previously vaccinated against or infected with SARS-CoV. |
