| First Author | Stopsack KH | Year | 2020 |
| Journal | Cancer Discov | Volume | 10 |
| Issue | 6 | Pages | 779-782 |
| PubMed ID | 32276929 | Mgi Jnum | J:288995 |
| Mgi Id | MGI:6431640 | Doi | 10.1158/2159-8290.CD-20-0451 |
| Citation | Stopsack KH, et al. (2020) TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?. Cancer Discov 10(6):779-782 |
| abstractText | TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections. |
