| First Author | Liu Y | Year | 2019 |
| Journal | Pathol Res Pract | Volume | 215 |
| Issue | 8 | Pages | 152493 |
| PubMed ID | 31201067 | Mgi Jnum | J:289284 |
| Mgi Id | MGI:6434947 | Doi | 10.1016/j.prp.2019.152493 |
| Citation | Liu Y, et al. (2019) Interleukin-34 drives macrophage polarization to the M2 phenotype in autoimmune hepatitis. Pathol Res Pract 215(8):152493 |
| abstractText | BACKGROUND: Autoimmune hepatitis is a chronic inflammatory disease, the abnormal immunological function is the main pathogenesis. Interleukin-34 is a newly identified cytokine that shares the same receptor as colony stimulating factor-1. METHODS: We used interleukin-34 knockout and wild-type mice in a Con A-induced hepatitis model and cocultured RAW264.7 macrophage cells with interleukin-34. We then detected associated inflammatory cytokine and chemokine levels to elucidate the role of interleukin-34. RESULTS: In this study, we found that the loss of interleukin-34 resulted in higher sensitivity to Con A-induced hepatitis. RAW264.7 macrophage cells were able to differentiate to the M2 phenotype upon interleukin-34 stimulation. CONCLUSIONS: We conclude that interleukin-34 may protect the liver from Con A-mediated hepatitis by driving M2 macrophage polarization and suppressing inflammation. |
