| First Author | Giri BR | Year | 2019 |
| Journal | Int J Parasitol | Volume | 49 |
| Issue | 13-14 | Pages | 993-997 |
| PubMed ID | 31726056 | Mgi Jnum | J:290439 |
| Mgi Id | MGI:6435356 | Doi | 10.1016/j.ijpara.2019.08.002 |
| Citation | Giri BR, et al. (2019) Host miR-148 regulates a macrophage-mediated immune response during Schistosoma japonicum infection. Int J Parasitol 49(13-14):993-997 |
| abstractText | Extracellular vesicles are critical regulators of host-parasite interactions. We previously demonstrated that Schistosoma japonicum EVs contain a remarkably high abundance of host miR-148a. Here, we characterised the abundance of miR-148a in circulation, in peripheral immune cells, and in plasma EVs of S. japonicum-infected mice. The results suggested the high abundance of miR-148a in macrophages to be likely linked to S. japonicum EVs. Additionally, miR-148a was found to target PTEN through the PI3K/AKT pathway to regulate cytokine production in macrophages. Consequently, our findings suggest that high abundance of miR-148a in macrophages may be associated with S. japonicum EVs, and regulate the host immune response during schistosome infection. |
