| First Author | Brdicková N | Year | 2003 |
| Journal | J Exp Med | Volume | 198 |
| Issue | 10 | Pages | 1453-62 |
| PubMed ID | 14610046 | Mgi Jnum | J:289012 |
| Mgi Id | MGI:6436209 | Doi | 10.1084/jem.20031484 |
| Citation | Brdickova N, et al. (2003) LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. J Exp Med 198(10):1453-62 |
| abstractText | Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck-interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. Thus, LIME appears to be involved in regulation of T cell activation by coreceptors. |
