| First Author | Lv H | Year | 2020 |
| Journal | Cell Rep | Volume | 31 |
| Issue | 9 | Pages | 107725 |
| PubMed ID | 32426212 | Mgi Jnum | J:291886 |
| Mgi Id | MGI:6448802 | Doi | 10.1016/j.celrep.2020.107725 |
| Citation | Lv H, et al. (2020) Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections. Cell Rep 31(9):107725 |
| abstractText | The World Health Organization has declared the ongoing outbreak of COVID-19, which is caused by a novel coronavirus SARS-CoV-2, a pandemic. There is currently a lack of knowledge about the antibody response elicited from SARS-CoV-2 infection. One major immunological question concerns antigenic differences between SARS-CoV-2 and SARS-CoV. We address this question by analyzing plasma from patients infected by SARS-CoV-2 or SARS-CoV and from infected or immunized mice. Our results show that, although cross-reactivity in antibody binding to the spike protein is common, cross-neutralization of the live viruses may be rare, indicating the presence of a non-neutralizing antibody response to conserved epitopes in the spike. Whether such low or non-neutralizing antibody response leads to antibody-dependent disease enhancement needs to be addressed in the future. Overall, this study not only addresses a fundamental question regarding antigenicity differences between SARS-CoV-2 and SARS-CoV but also has implications for immunogen design and vaccine development. |
