| First Author | Cai SZ | Year | 2019 |
| Journal | Biosci Rep | Volume | 39 |
| Issue | 7 | PubMed ID | 31213573 |
| Mgi Jnum | J:295860 | Mgi Id | MGI:6455235 |
| Doi | 10.1042/BSR20190243 | Citation | Cai SZ, et al. (2019) Allicin alleviates lead-induced hematopoietic stem cell aging by up-regulating PKM2. Biosci Rep 39(7) |
| abstractText | Hematopoietic stem cells (HSCs) aging is associated with hematopoietic dysfunction and diseases. Our previous study showed that lead exposure induced a functional decline in HSCs. Allicin, a chemical extracted from the garlic (Allium sativum L.), has been reported to have antioxidative and anti-inflammatory effects. However, the biological activities of allicin on lead-induced toxicity, especially in the hematopoietic system, remain unclear. Here, we found that lead exposure elicited aging phenotypes in HSCs, including perturbed cell quiescence, disabled self-renewal function and colony-forming ability, and myeloid-biased differentiation, all of which contributed to significant hematopoietic disorders in mice. Intragastric administration of allicin substantially ameliorated lead-induced HSCs aging phenotypes in vivo Lead exposure induced a peroxide condition in HSCs leading to DNA damage, which reduced expression of the glycolytic enzyme pyruvate kinase M2 isoform (PKM2), a phenotype which was significantly ameliorated by allicin treatment. These findings suggested that allicin alleviated lead-induced HSCs aging by up-regulating PKM2 expression; thus, it could be a natural herb for preventing lead toxicity. |
