| First Author | Kilgore AM | Year | 2018 |
| Journal | Immunohorizons | Volume | 2 |
| Issue | 1 | Pages | 1-11 |
| PubMed ID | 29354801 | Mgi Jnum | J:293533 |
| Mgi Id | MGI:6453285 | Doi | 10.4049/immunohorizons.1700054 |
| Citation | Kilgore AM, et al. (2018) IL-27p28 Production by XCR1(+) Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8(+) T Cell Responses. Immunohorizons 2(1):1-11 |
| abstractText | It is well accepted that the innate response is a necessary prerequisite to the formation of the adaptive response. This is true for T cell responses against infections or adjuvanted subunit vaccination. However, specific innate parameters with predictive value for the magnitude of an adjuvant-elicited T cell response have yet to be identified. We previously reported how T cell responses induced by subunit vaccination were dependent on the cytokine IL-27. These findings were unexpected, given that T cell responses to an infection typically increase in the absence of IL-27. Using a novel IL-27p28-eGFP reporter mouse, we now show that the degree to which an adjuvant induces IL-27p28 production from dendritic cells and monocytes directly predicts the magnitude of the T cell response elicited. To our knowledge, these data are the first to identify a concrete innate correlate of vaccine-elicited cellular immunity, and they have significant practical and mechanistic implications for subunit vaccine biology. |
