| First Author | Iwaki T | Year | 2019 |
| Journal | Physiol Rep | Volume | 7 |
| Issue | 10 | Pages | e14078 |
| PubMed ID | 31102342 | Mgi Jnum | J:295591 |
| Mgi Id | MGI:6454001 | Doi | 10.14814/phy2.14078 |
| Citation | Iwaki T, et al. (2019) PPARalpha contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis. Physiol Rep 7(10):e14078 |
| abstractText | Sepsis-associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis-associated AKI are poorly understood. Previous research has demonstrated that peroxisome proliferator-activated receptor alpha (PPARalpha) expression is associated with reduced organ system failure in sepsis. Using an experimental model of polymicrobial sepsis, we demonstrate that mice deficient in PPARalpha have worse kidney function, which is likely related to reduced fatty acid oxidation and increased inflammation. Ultrastructural evaluation with electron microscopy reveals that the proximal convoluted tubule is specifically injured in septic PPARalpha deficient mice. In this experimental group, serum metabolomic analysis reveals unanticipated metabolic derangements in tryptophan-kynurenine-NAD(+) and pantothenate pathways. We also show that a subgroup of children with sepsis whose genome-wide expression profiles are characterized by repression of the PPARalpha signaling pathway has increased incidence of severe AKI. These findings point toward interesting associations between sepsis-associated AKI and PPARalpha-driven fatty acid metabolism that merit further investigation. |
