| First Author | Chikahisa S | Year | 2019 |
| Journal | Behav Brain Res | Volume | 359 |
| Pages | 664-670 | PubMed ID | 30278189 |
| Mgi Jnum | J:295693 | Mgi Id | MGI:6454236 |
| Doi | 10.1016/j.bbr.2018.09.020 | Citation | Chikahisa S, et al. (2019) Enhancement of fear learning in PPARalpha knockout mice. Behav Brain Res 359:664-670 |
| abstractText | Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the nuclear receptor superfamily and regulates fatty acid oxidation. Although PPARalpha is expressed not only in the peripheral tissues but also in the brain, its role in higher brain function is unclear. In this study, we investigated the role of PPARalpha in the control of behavior, including memory/learning and mood change, using PPARalpha knockout (KO) mice. A significant difference between wild-type (WT) and KO mice was seen in the passive avoidance test, demonstrating that KO mice showed enhanced fear leaning. In the amygdala of KO mice, the levels of dopamine and its metabolites were increased, and the mRNA expression of dopamine degrading enzyme was decreased. When dopamine D1 receptor antagonist was administered, the enhanced fear learning observed in KO mice was attenuated. These results suggest that PPARalpha is involved in the regulation of emotional memory via the dopamine pathway in the amygdala. |
