First Author | van Oosterwijk JG | Year | 2019 |
Journal | Oncotarget | Volume | 10 |
Issue | 12 | Pages | 1235-1237 |
PubMed ID | 30815226 | Mgi Jnum | J:298130 |
Mgi Id | MGI:6457213 | Doi | 10.18632/oncotarget.26651 |
Citation | van Oosterwijk JG, et al. (2019) Sexually dimorphic tumor suppression by small mitochondrial Arf. Oncotarget 10(12):1235-1237 |
abstractText | Internal translational initiation of the mRNA encoding the Arf tumor suppressor yields an N-terminally truncated small Arf protein (smArf) that lacks amino acid residues required for Mdm2 binding and p53 activation. Here, we report that female, but not male, mice engineered to produce only smArf in lieu of the full-length Arf protein retain residual, sexually dimorphic tumor suppressive activity. |