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Publication : Sexually dimorphic tumor suppression by small mitochondrial <i>Arf</i>.

First Author  van Oosterwijk JG Year  2019
Journal  Oncotarget Volume  10
Issue  12 Pages  1235-1237
PubMed ID  30815226 Mgi Jnum  J:298130
Mgi Id  MGI:6457213 Doi  10.18632/oncotarget.26651
Citation  van Oosterwijk JG, et al. (2019) Sexually dimorphic tumor suppression by small mitochondrial Arf. Oncotarget 10(12):1235-1237
abstractText  Internal translational initiation of the mRNA encoding the Arf tumor suppressor yields an N-terminally truncated small Arf protein (smArf) that lacks amino acid residues required for Mdm2 binding and p53 activation. Here, we report that female, but not male, mice engineered to produce only smArf in lieu of the full-length Arf protein retain residual, sexually dimorphic tumor suppressive activity.
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