| First Author | Zriwil A | Year | 2018 |
| Journal | Br J Haematol | Volume | 183 |
| Issue | 4 | Pages | 588-600 |
| PubMed ID | 30596405 | Mgi Jnum | J:295115 |
| Mgi Id | MGI:6459657 | Doi | 10.1111/bjh.15578 |
| Citation | Zriwil A, et al. (2018) Direct role of FLT3 in regulation of early lymphoid progenitors. Br J Haematol 183(4):588-600 |
| abstractText | Given that FLT3 expression is highly restricted on lymphoid progenitors, it is possible that the established role of FLT3 in the regulation of B and T lymphopoiesis reflects its high expression and role in regulation of lymphoid-primed multipotent progenitors (LMPPs) or common lymphoid progenitors (CLPs). We generated a Flt3 conditional knock-out (Flt3(fl/fl)) mouse model to address the direct role of FLT3 in regulation of lymphoid-restricted progenitors, subsequent to turning on Rag1 expression, as well as potentially ontogeny-specific roles in B and T lymphopoiesis. Our studies establish a prominent and direct role of FLT3, independently of the established role of FLT3 in regulation of LMPPs and CLPs, in regulation of fetal as well as adult early B cell progenitors, and the early thymic progenitors (ETPs) in adult mice but not in the fetus. Our findings highlight the potential benefit of targeting poor prognosis acute B-cell progenitor leukaemia and ETP leukaemia with recurrent FLT3 mutations using clinical FLT3 inhibitors. |
