| First Author | Cantuti-Castelvetri L | Year | 2020 |
| Journal | Science | Volume | 370 |
| Issue | 6518 | Pages | 856-860 |
| PubMed ID | 33082293 | Mgi Jnum | J:297122 |
| Mgi Id | MGI:6471959 | Doi | 10.1126/science.abd2985 |
| Citation | Cantuti-Castelvetri L, et al. (2020) Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science 370(6518):856-860 |
| abstractText | The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by the availability of virus receptors and entry cofactors on the surface of host cells. In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1. A SARS-CoV-2 mutant with an altered furin cleavage site did not depend on NRP1 for infectivity. Pathological analysis of olfactory epithelium obtained from human COVID-19 autopsies revealed that SARS-CoV-2 infected NRP1-positive cells facing the nasal cavity. Our data provide insight into SARS-CoV-2 cell infectivity and define a potential target for antiviral intervention. |
