|  Help  |  About  |  Contact Us

Publication : Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.

First Author  Cantuti-Castelvetri L Year  2020
Journal  Science Volume  370
Issue  6518 Pages  856-860
PubMed ID  33082293 Mgi Jnum  J:297122
Mgi Id  MGI:6471959 Doi  10.1126/science.abd2985
Citation  Cantuti-Castelvetri L, et al. (2020) Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science 370(6518):856-860
abstractText  The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by the availability of virus receptors and entry cofactors on the surface of host cells. In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1. A SARS-CoV-2 mutant with an altered furin cleavage site did not depend on NRP1 for infectivity. Pathological analysis of olfactory epithelium obtained from human COVID-19 autopsies revealed that SARS-CoV-2 infected NRP1-positive cells facing the nasal cavity. Our data provide insight into SARS-CoV-2 cell infectivity and define a potential target for antiviral intervention.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

3 Bio Entities

Trail: Publication

0 Expression