Other
13 Authors
- Chen R,
- Wu G,
- Mildner K,
- Adachi K,
- Wu J,
- Kim YS,
- Galatidou S,
- Bedzhov I,
- Schöler HR,
- Leidel SA,
- Fan R,
- Zeuschner D,
- Li J
| First Author | Fan R | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 5499 |
| PubMed ID | 33127892 | Mgi Jnum | J:297709 |
| Mgi Id | MGI:6479179 | Doi | 10.1038/s41467-020-19353-0 |
| Citation | Fan R, et al. (2020) Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause. Nat Commun 11(1):5499 |
| abstractText | The epiblast, which provides the foundation of the future body, is actively reshaped during early embryogenesis, but the reshaping mechanisms are poorly understood. Here, using a 3D in vitro model of early epiblast development, we identify the canonical Wnt/beta-catenin pathway and its central downstream factor Esrrb as the key signalling cascade regulating the tissue-scale organization of the murine pluripotent lineage. Although in vivo the Wnt/beta-catenin/Esrrb circuit is dispensable for embryonic development before implantation, autocrine Wnt activity controls the morphogenesis and long-term maintenance of the epiblast when development is put on hold during diapause. During this phase, the progressive changes in the epiblast architecture and Wnt signalling response show that diapause is not a stasis but instead is a dynamic process with underlying mechanisms that can appear redundant during transient embryogenesis. |
