| Help | About | Contact Us

Publication : Aberrant type 1 immunity drives susceptibility to mucosal fungal infections.

First Author	Break TJ	Year	2021
Journal	Science	Volume	371
Issue	6526	PubMed ID	33446526
Mgi Jnum	J:300010	Mgi Id	MGI:6501612
Doi	10.1126/science.aay5731	Citation	Break TJ, et al. (2021) Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science 371(6526)

abstractText

Human monogenic disorders have revealed the critical contribution of type 17 responses in mucosal fungal surveillance. We unexpectedly found that in certain settings, enhanced type 1 immunity rather than defective type 17 responses can promote mucosal fungal infection susceptibility. Notably, in mice and humans with AIRE deficiency, an autoimmune disease characterized by selective susceptibility to mucosal but not systemic fungal infection, mucosal type 17 responses are intact while type 1 responses are exacerbated. These responses promote aberrant interferon-gamma (IFN-gamma)- and signal transducer and activator of transcription 1 (STAT1)-dependent epithelial barrier defects as well as mucosal fungal infection susceptibility. Concordantly, genetic and pharmacologic inhibition of IFN-gamma or Janus kinase (JAK)-STAT signaling ameliorates mucosal fungal disease. Thus, we identify aberrant T cell-dependent, type 1 mucosal inflammation as a critical tissue-specific pathogenic mechanism that promotes mucosal fungal infection susceptibility in mice and humans.

Expression

Publication --> Expression annotations

Other

43 Authors

Hoffman KW,
Anderson MS,
Lee CR,
Dutzan N,
Olbrich P,
Lim JK,
Freiwald T,
Oikonomou V,
Chauss D,
Hickman HD,
Bouladoux N,
Genomics and Computational Biology Core.,
Matsumoto M,
Pontejo SM,
Barber DL,
Bruno VM,
Williams DW,
Greenwell-Wild T,
Shannon JP,
Swamydas M,
Rosen LB,
Lwin W,
Filler SG,
Martin D,
Schmitt M,
Lionakis MS,
Break TJ,
Pittaluga S,
Notarangelo LD,
Murphy PM,
Holland SM,
Harrison OJ,
Alejo J,
Solis NV,
Renteria A,
Desai JV,
Ferré EMN,
Serreze DV,
Afzali B,
Swidergall M,
Belkaid Y,
Moutsopoulos NM,
Myles IA

0 Bio Entities

0 Expression

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/report.do?id=83960615

MouseMine