| First Author | Mishra S | Year | 2021 |
| Journal | J Exp Med | Volume | 218 |
| Issue | 1 | PubMed ID | 32991667 |
| Mgi Jnum | J:307774 | Mgi Id | MGI:6509786 |
| Doi | 10.1084/jem.20200030 | Citation | Mishra S, et al. (2021) TGF-beta and Eomes control the homeostasis of CD8+ regulatory T cells. J Exp Med 218(1) |
| abstractText | In addition to Foxp3+ CD4+ regulatory T cells (CD4+ T reg cells), Foxp3- CD8+ regulatory T cells (CD8+ T reg cells) are critical to maintain immune tolerance. However, the molecular programs that specifically control CD8+ but not CD4+ T reg cells are largely unknown. Here, we demonstrate that simultaneous disruption of both TGF-beta receptor and transcription factor Eomesodermin (Eomes) in T cells results in lethal autoimmunity due to a specific defect in CD8+ but not CD4+ T reg cells. Further, TGF-beta signal maintains the regulatory identity, while Eomes controls the follicular location of CD8+ T reg cells. Both TGF-beta signal and Eomes coordinate to promote the homeostasis of CD8+ T reg cells. Together, we have identified a unique molecular program designed for CD8+ T reg cells. |
