| First Author | Suddason T | Year | 2016 |
| Journal | Cell Cycle | Volume | 15 |
| Issue | 15 | Pages | 1956-60 |
| PubMed ID | 27246297 | Mgi Jnum | J:303016 |
| Mgi Id | MGI:6510195 | Doi | 10.1080/15384101.2016.1189042 |
| Citation | Suddason T, et al. (2016) Genetic insights into Map3k-dependent proliferative expansion of T cells. Cell Cycle 15(15):1956-60 |
| abstractText | Mapks are important regulators of T cell proliferative expansion and cell cycle progression. Detailed genetic analysis of unconventional iNKT cells in both Map3k1(DeltaKD) and Lck(Cre/+)Map3k1(f/f) mice demonstrated that Mekk1 (encoded by Map3k1) signaling activates Mapks to regulate Cdkn1b (encoding p27(Kip1)) expression and p27(Kip1)-dependent proliferative expansion in response to antigen. Mekk1 signaling and activation of E3 ubiquitin ligase Itch, by a phosphorylation-dependent conformational change, is also an important regulatory mechanism for the control of T helper cell cytokine production. Cdkn1b expression is regulated by Mekk1-dependent signaling in differentiated Th17 cells. Mekk1 is one of the 19 Ste11-like Map3ks, and Mekk1 signaling regulates iNKT cell proliferative expansion in response to glycolipid antigens and T cell homeostasis in the liver. Tak1 (encoded by Map3k7), a related Map3k to Mekk1, similarly regulates the proliferative expansion and homeostasis of T cells in the liver, and this illustrates the importance of multiple Map3ks for mammalian Mapk signaling. |
