| First Author | L'homme L | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 21095 |
| PubMed ID | 33273527 | Mgi Jnum | J:299591 |
| Mgi Id | MGI:6491014 | Doi | 10.1038/s41598-020-77858-6 |
| Citation | L'homme L, et al. (2020) Deletion of the nuclear receptor RORalpha in macrophages does not modify the development of obesity, insulin resistance and NASH. Sci Rep 10(1):21095 |
| abstractText | Retinoic acid receptor-related orphan receptor-alpha (RORalpha) is a transcription factor from the nuclear receptor family expressed by immune cells and involved in the development of obesity, insulin resistance (IR) and non-alcoholic steatohepatitis (NASH). It was recently reported that mice deficient for RORalpha in macrophages develop more severe NASH upon high fat diet (HFD) feeding due to altered Kupffer cell function. To better understand the role of RORalpha in obesity and IR, we independently generated a macrophage RORalpha-deficient mouse line. We report that RORalpha deletion in macrophages does not impact on HFD-induced obesity and IR. Surprisingly, we did not confirm an effect on NASH development upon HFD feeding nor in the more severe and obesity-independent choline-deficient, L-amino acid-defined diet model. Our results therefore show that RORalpha deletion in macrophages does not alter the development of obesity and IR and question its role in NASH. |
