| First Author | Ho BL | Year | 2021 |
| Journal | FEBS Lett | Volume | 595 |
| Issue | 5 | Pages | 655-666 |
| PubMed ID | 33421114 | Mgi Jnum | J:305063 |
| Mgi Id | MGI:6510441 | Doi | 10.1002/1873-3468.14034 |
| Citation | Ho BL, et al. (2021) NRG/ErbB signaling regulates neonatal muscle growth but not neuromuscular contractures in neonatal brachial plexus injury. FEBS Lett 595(5):655-666 |
| abstractText | Neonatal brachial plexus injury (NBPI) causes disabling and incurable muscle contractures that are driven by impaired growth of denervated muscles. A rare form of NBPI, which maintains afferent muscle innervation despite motor denervation, does not cause contractures. As afferent innervation regulates various aspects of skeletal muscle homeostasis through NRG/ErbB signaling, our current study investigated the role of this pathway in modulating contracture development. Through pharmacologic modification with an ErbB antagonist and NRG1 isoforms, we discovered that NRG/ErbB signaling does not modulate the development of contractures in neonatal mice. Instead, ErbB inhibition impeded growth in nondenervated skeletal muscles, whereas increased ErbB activation exacerbated denervation-induced skeletal muscle atrophy. This potential regulatory effect of NRG/ErbB signaling on neonatal muscle growth warrants deeper investigation. |
