| First Author | Bai L | Year | 2021 |
| Journal | Science | Volume | 371 |
| Issue | 6536 | PubMed ID | 33766856 |
| Mgi Jnum | J:305038 | Mgi Id | MGI:6512989 |
| Doi | 10.1126/science.aba4177 | Citation | Bai L, et al. (2021) Liver type 1 innate lymphoid cells develop locally via an interferon-gamma-dependent loop. Science 371(6536) |
| abstractText | The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. We show here that the adult mouse liver contains Lin(-)Sca-1(+)Mac-1(+) hematopoietic stem cells derived from the fetal liver. This population includes Lin(-)CD122(+)CD49a(+) progenitors that can generate liver ILC1s but not conventional natural killer cells. Interferon-gamma (IFN-gamma) production by the liver ILC1s themselves promotes the development of these cells in situ, through effects on their IFN-gammaR(+) liver progenitors. Thus, an IFN-gamma-dependent loop drives liver ILC1 development in situ, highlighting the contribution of extramedullary hematopoiesis to regional immune composition within the liver. |
