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Publication : Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.

First Author  Brouwer PJM Year  2021
Journal  Cell Volume  184
Issue  5 Pages  1188-1200.e19
PubMed ID  33577765 Mgi Jnum  J:303464
Mgi Id  MGI:6514605 Doi  10.1016/j.cell.2021.01.035
Citation  Brouwer PJM, et al. (2021) Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection. Cell 184(5):1188-1200.e19
abstractText  The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.
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