| First Author | Wang P | Year | 2021 |
| Journal | Biochem Biophys Res Commun | Volume | 545 |
| Pages | 195-202 | PubMed ID | 33571908 |
| Mgi Jnum | J:305608 | Mgi Id | MGI:6706072 |
| Doi | 10.1016/j.bbrc.2021.01.079 | Citation | Wang P, et al. (2021) miR-128 regulates epilepsy sensitivity in mice by suppressing SNAP-25 and SYT1 expression in the hippocampus. Biochem Biophys Res Commun 545:195-202 |
| abstractText | Epilepsy is accompanied by abnormal neurotransmission, and microRNAs, as versatile players in the modulation of gene expression, are important in epilepsy pathology. Here, we found that miR-128 expression was elevated in the acute seizure phase and decreased during the recurrent seizure phase after status epilepticus in mice. Both SNAP-25 and SYT1 are regulated by miR-128 in vitro and in vivo. Overexpressing miR-128 in cultured neurons decreased neurotransmitter released by suppressing SNAP-25 and SYT1 expression. Anti-miR-128 injection before kainic acid (KA) injection increased the sensitivity of mice to KA-induced seizures, while overexpressing miR-128 at the latent and recurrent phases had a neuroprotective effect in KA-induced seizures. Our study shows for the first time that miR-128, a key regulator of neurotransmission, plays an important role in epilepsy pathology and that miR-128 might be a potential candidate molecular target for epilepsy therapy. |
