| First Author | Alves de Lima K | Year | 2020 |
| Journal | Nat Immunol | Volume | 21 |
| Issue | 11 | Pages | 1421-1429 |
| PubMed ID | 32929273 | Mgi Jnum | J:305304 |
| Mgi Id | MGI:6706381 | Doi | 10.1038/s41590-020-0776-4 |
| Citation | Alves de Lima K, et al. (2020) Meningeal gammadelta T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nat Immunol 21(11):1421-1429 |
| abstractText | Interleukin (IL)-17a has been highly conserved during evolution of the vertebrate immune system and widely studied in contexts of infection and autoimmunity. Studies suggest that IL-17a promotes behavioral changes in experimental models of autism and aggregation behavior in worms. Here, through a cellular and molecular characterization of meningeal gammadelta17 T cells, we defined the nearest central nervous system-associated source of IL-17a under homeostasis. Meningeal gammadelta T cells express high levels of the chemokine receptor CXCR6 and seed meninges shortly after birth. Physiological release of IL-17a by these cells was correlated with anxiety-like behavior in mice and was partially dependent on T cell receptor engagement and commensal-derived signals. IL-17a receptor was expressed in cortical glutamatergic neurons under steady state and its genetic deletion decreased anxiety-like behavior in mice. Our findings suggest that IL-17a production by meningeal gammadelta17 T cells represents an evolutionary bridge between this conserved anti-pathogen molecule and survival behavioral traits in vertebrates. |
