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Publication : The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas.

First Author  Caruso V Year  2014
Journal  Gene Volume  553
Issue  1 Pages  1-6
PubMed ID  25275856 Mgi Jnum  J:309257
Mgi Id  MGI:6708303 Doi  10.1016/j.gene.2014.09.042
Citation  Caruso V, et al. (2014) The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas. Gene 553(1):1-6
abstractText  The Rhodopsin family is a class of integral membrane proteins belonging to G protein-coupled receptors (GPCRs). To date, several orphan GPCRs are still uncharacterized and in this study we present an anatomical characterization of the GPR162 protein and an attempt to describe its functional role. Our results show that GPR162 is widely expressed in GABAergic as well as other neurons within the mouse hippocampus, whereas extensive expression is observed in areas related to energy homeostasis and hedonic feeding such as hypothalamus, amygdala and ventral tegmental area, regions known to be involved in the regulation of palatable food consumption.
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