| First Author | Yang X | Year | 2021 |
| Journal | Behav Brain Res | Volume | 406 |
| Pages | 113232 | PubMed ID | 33705839 |
| Mgi Jnum | J:316850 | Mgi Id | MGI:6709753 |
| Doi | 10.1016/j.bbr.2021.113232 | Citation | Yang X, et al. (2021) Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice. Behav Brain Res 406:113232 |
| abstractText | Ultrasonic vocalization (USV) characterization is useful for evaluating communication in mouse models of autism spectrum disorder (ASD). Here, by categorizing USVs into 12 types using a comprehensive classification method, we obtained the qualitative and quantitative characteristics of USV repertoire emitted by ASD-related Dock4 knockout (KO) mice and their wild-type (WT) littermates during social isolation over early postnatal development. Notably, USVs emitted by WT pups exhibited a developmental switch from a pattern with more multiple-note calls, which have more complex acoustic structure, lower pitch and larger volume, into one with more single-note calls, which have simpler acoustic structure, higher pitch and smaller volume. Comparing with WT pups, USVs emitted by Dock4 KO pups had larger volume and consisted of more multiple-note calls with higher pitch in later developmental stage. These findings collectively reveal a developmental pattern of USV in normal mice and identified a set of alterations in Dock4 KO pups. |
