| First Author | Lee J | Year | 2021 |
| Journal | Sci Rep | Volume | 11 |
| Issue | 1 | Pages | 16348 |
| PubMed ID | 34381063 | Mgi Jnum | J:359915 |
| Mgi Id | MGI:6754970 | Doi | 10.1038/s41598-021-94855-5 |
| Citation | Lee J, et al. (2021) Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-alpha in transgenic mice. Sci Rep 11(1):16348 |
| abstractText | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-alpha, which leads to an autoimmune reaction and exacerbates lupus-like symptoms. |
