| First Author | Tordoff MG | Year | 2015 |
| Journal | Chem Senses | Volume | 40 |
| Issue | 7 | Pages | 453-9 |
| PubMed ID | 25987548 | Mgi Jnum | J:315379 |
| Mgi Id | MGI:6830288 | Doi | 10.1093/chemse/bjv025 |
| Citation | Tordoff MG, et al. (2015) Normal Taste Acceptance and Preference of PANX1 Knockout Mice. Chem Senses 40(7):453-9 |
| abstractText | Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1. |
