| First Author | Koyas A | Year | 2021 |
| Journal | Sci Signal | Volume | 14 |
| Issue | 674 | PubMed ID | 33727336 |
| Mgi Jnum | J:308850 | Mgi Id | MGI:6751904 |
| Doi | 10.1126/scisignal.abb1269 | Citation | Koyas A, et al. (2021) Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression. Sci Signal 14(674) |
| abstractText | The nucleoside adenosine accumulates extracellularly in solid tumors and inhibits CD8(+) T cells by activating adenosine receptors. The cytokine interleukin-7 (IL-7), which is produced by various tissues and tumors, promotes the survival and maintenance of T cells. Adenosine and IL-7 signaling are being clinically targeted separately or in combination with other therapies for solid tumor indications. Here, we found that IL-7 signaling promoted the accumulation of tumor-associated CD8(+) T cells, in part, by preventing adenosine-mediated immunosuppression. Inhibition of the transcription factor FoxO1 downstream of IL-7 receptor signaling was important for protecting CD8(+) T cells from suppression by adenosine. These findings have implications for the development of new approaches for cancer immunotherapies that target the adenosine pathway. |
