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Publication : A Prdm8 target gene Ebf3 regulates multipolar-to-bipolar transition in migrating neocortical cells.

First Author  Iwai R Year  2018
Journal  Biochem Biophys Res Commun Volume  495
Issue  1 Pages  388-394
PubMed ID  29113800 Mgi Jnum  J:316455
Mgi Id  MGI:6838226 Doi  10.1016/j.bbrc.2017.11.021
Citation  Iwai R, et al. (2018) A Prdm8 target gene Ebf3 regulates multipolar-to-bipolar transition in migrating neocortical cells. Biochem Biophys Res Commun 495(1):388-394
abstractText  Precise control of neuronal migration is essential for the development of the neocortex. However, the molecular mechanisms underlying neuronal migration remain largely unknown. Here we identified helix-loop-helix transcription factor Ebf3 as a Prdm8 target gene, and found that Ebf3 is a key regulator of neuronal migration via multipolar-to-bipolar transition. Ebf3 knockdown cells exhibited severe defects in the formation of leading processes and an inhibited shift to the locomotion mode. Moreover, we found that Ebf3 knockdown represses NeuroD1 transcription, and NeuroD1 overexpression partially rescued migration defects in Ebf3 knockdown cells. Our findings highlight the critical role of Ebf3 in multipolar-to-bipolar transition via positive feedback regulation of NeuroD1 in the developing neocortex.
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