| First Author | Yang Y | Year | 2016 |
| Journal | Cell Res | Volume | 26 |
| Issue | 3 | Pages | 288-303 |
| PubMed ID | 26823206 | Mgi Jnum | J:316816 |
| Mgi Id | MGI:6838710 | Doi | 10.1038/cr.2016.16 |
| Citation | Yang Y, et al. (2016) The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response. Cell Res 26(3):288-303 |
| abstractText | Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to induction of interferons (IFNs) and proinflammatory cytokines, and innate antiviral response. Here we identified the RNA-binding protein Mex3B as a positive regulator of TLR3-mediated signaling by expression cloning screens. Cells from Mex3b(-/-) mice exhibited reduced production of IFN-beta in response to the dsRNA analog poly(I:C) but not infection with RNA viruses. Mex3b(-/-) mice injected with poly(I:C) was more resistant to poly(I:C)-induced death. Mex3B was associated with TLR3 in the endosomes. It bound to dsRNA and increased the dsRNA-binding activity of TLR3. Mex3B also promoted the proteolytic processing of TLR3, which is critical for its activation. Mutants of Mex3B lacking its RNA-binding activity inhibited TLR3-mediated IFN-beta induction. These findings suggest that Mex3B acts as a coreceptor of TLR3 in innate antiviral response. |
