| First Author | Balamurugan K | Year | 2013 |
| Journal | Int J Biol Sci | Volume | 9 |
| Issue | 9 | Pages | 917-33 |
| PubMed ID | 24155666 | Mgi Jnum | J:316828 |
| Mgi Id | MGI:6840532 | Doi | 10.7150/ijbs.7224 |
| Citation | Balamurugan K, et al. (2013) The many faces of C/EBPdelta and their relevance for inflammation and cancer. Int J Biol Sci 9(9):917-33 |
| abstractText | The CCAAT/enhancer binding protein delta (CEBPD, C/EBPdelta) is a transcription factor that modulates many biological processes including cell differentiation, motility, growth arrest, proliferation, and cell death. The diversity of C/EBPdelta's functions depends in part on the cell type and cellular context and can have opposing outcomes. For example, C/EBPdelta promotes inflammatory signaling, but it can also inhibit pro-inflammatory pathways, and in a mouse model of mammary tumorigenesis, C/EBPdelta reduces tumor incidence but promotes tumor metastasis. This review highlights the multifaceted nature of C/EBPdelta's functions, with an emphasis on pathways that are relevant for cancer and inflammation, and illustrates how C/EBPdelta emerged from the shadow of its family members as a fascinating "jack of all trades." Our current knowledge on C/EBPdelta indicates that, rather than being essential for a specific cellular process, C/EBPdelta helps to interpret a variety of cues in a cell-type and context-dependent manner, to adjust cellular functions to specific situations. Therefore, insights into the roles and mechanisms of C/EBPdelta signaling can lead to a better understanding of how the integration of different signaling pathways dictates normal and pathological cell functions and physiology. |
