| First Author | Tabbaa M | Year | 2021 |
| Journal | PLoS One | Volume | 16 |
| Issue | 11 | Pages | e0260199 |
| PubMed ID | 34847180 | Mgi Jnum | J:315179 |
| Mgi Id | MGI:6830782 | Doi | 10.1371/journal.pone.0260199 |
| Citation | Tabbaa M, et al. (2021) Oxytocin receptor disruption in Avil-expressing cells results in blunted sociability and increased inter-male aggression. PLoS One 16(11):e0260199 |
| abstractText | Social behaviors are foundational to society and quality of life while social behavior extremes are core symptoms in a variety of psychopathologies and developmental disabilities. Oxytocin (OXT) is a neuroactive hormone that regulates social behaviors through its receptor (OXTR), with all previously identified social behavior effects attributed to the central nervous system, which has developmental origins in the neural tube. However, OXTR are also present in neural crest-derived tissue including sensory ganglia of the peripheral nervous system. Avil encodes for the actin-binding protein ADVILLIN, is expressed in neural crest-derived cells, and was therefore used as a target in this study to knock out OXTR expression in neural-crest derived cells. Here, we tested if OXTRs specifically expressed in Avil positive neural crest-derived cells are necessary for species-typical adult social behaviors using a Cre-LoxP strategy. Genetically modified male and female mice lacking OXTR in Avil expressing cells (OXTRAvil KO) were tested for sociability and preference for social novelty. Males were also tested for resident intruder aggression. OXTRAvil KO males and females had reduced sociability compared to OXTRAvil WT controls. Additionally, OXTRAvil KO males had increased aggressive behaviors compared to controls. These data indicate that OXTRs in cells of neural crest origin are important regulators of typical social behaviors in C57BL/6J adult male and female mice and point to needed directions of future research. |
