| First Author | Li Y | Year | 2018 |
| Journal | Cell Mol Immunol | Volume | 15 |
| Issue | 5 | Pages | 518-530 |
| PubMed ID | 28690333 | Mgi Jnum | J:315982 |
| Mgi Id | MGI:6831964 | Doi | 10.1038/cmi.2017.39 |
| Citation | Li Y, et al. (2018) Characterization and biological significance of IL-23-induced neutrophil polarization. Cell Mol Immunol 15(5):518-530 |
| abstractText | Neutrophils are heterogeneous with distinct subsets, and can switch phenotypes to exert regulatory functions on immunity. We herein demonstrate that IL-23-treated neutrophils selectively produce IL-17A, IL-17F and IL-22, and display a distinct gene expression profile in contrast to resting and lipopolysaccharide-treated neutrophils. IL-17(+) neutrophils are present in the colons of mice with dextran sulfate sodium-induced colitis. Adoptive transfer of IL-23-treated neutrophils significantly promotes pathogenesis in this model. IL-23 induces neutrophil polarization through STAT3-dependent RORgammat and BATF pathways. Thus, IL-23-induced neutrophil polarization expresses a unique cytokine-producing profile, which may contribute to IL-23-mediated inflammatory diseases. |
