| First Author | Zhang P | Year | 2014 |
| Journal | Can J Cardiol | Volume | 30 |
| Issue | 12 | Pages | 1684-8 |
| PubMed ID | 25475470 | Mgi Jnum | J:329666 |
| Mgi Id | MGI:6760202 | Doi | 10.1016/j.cjca.2014.09.019 |
| Citation | Zhang P, et al. (2014) Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation. Can J Cardiol 30(12):1684-8 |
| abstractText | We tested whether loss of eukaryotic elongation factor 2 kinase (eEF2K) activity in macrophages suppresses development of atherosclerosis by transplanting bone marrow from mice with mutant eEF2K into ldlr(-/-) mice. Sixteen weeks after high-fat diet feeding, mutant eEF2K hematopoietic chimeras had a dramatically reduced level of atherosclerotic plaque formation. M1-skewed macrophages from eEF2K knock-in mice have less tumour necrosis factor-alpha release and a lesser ability to induce expression of endothelial cell markers, providing a potential explanation for the role of eEF2K. Because eEF2K activity in cells of the hematopoietic compartment contributes to atherosclerosis development, drugs inhibiting eEF2K might have a beneficial effect in treatment of atherosclerosis. |
